THE REGULATORY ROLE OF Vα14 NKT CELLS IN INNATE AND ACQUIRED IMMUNE RESPONSE
Taniguchi, Masaru; Harada, Michishige; Kojo, Satoshi; Nakayama, Toshinori; Wakao, Hiroshi; Taniguchi, Masaru; Laboratory of Immune Regulation, RIKEN Research Center for Allergy and Immunology, and Department of Molecular Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan; email: taniguti@med.m.chiba-u.ac.jp harada@med.m.chiba-u.ac.jp skojo@med.m.chiba-u.ac.jp nakayama@med.m.chiba-u.ac.jp hwakao@med.m.chiba-u.ac.jp
Журнал:
Annual Review of Immunology
Дата:
2003
Аннотация:
▪ Abstract A novel lymphocyte lineage, Vα14 natural killer T (NKT) cells, is now well established as distinct from conventional αβ T cells. Vα14 NKT cells express a single invariant Vα14 antigen receptor that is essential for their development. Successful identification of a specific ligand, α-galactosylceramide(α-GalCer), and the establishment of gene-manipulated mice with selective loss of Vα14 NKT cells helped elucidate the remarkable functional diversity of Vα14 NKT cells in various immune responses such as host defense by mediating anti-nonself innate immune reaction, homeostatic regulation of anti-self responses, and antitumor immunity.
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