| Автор | Taniguchi, Masaru |
| Автор | Harada, Michishige |
| Автор | Kojo, Satoshi |
| Автор | Nakayama, Toshinori |
| Автор | Wakao, Hiroshi |
| Дата выпуска | 2003 |
| dc.description | ▪ Abstract A novel lymphocyte lineage, Vα14 natural killer T (NKT) cells, is now well established as distinct from conventional αβ T cells. Vα14 NKT cells express a single invariant Vα14 antigen receptor that is essential for their development. Successful identification of a specific ligand, α-galactosylceramide(α-GalCer), and the establishment of gene-manipulated mice with selective loss of Vα14 NKT cells helped elucidate the remarkable functional diversity of Vα14 NKT cells in various immune responses such as host defense by mediating anti-nonself innate immune reaction, homeostatic regulation of anti-self responses, and antitumor immunity. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | THE REGULATORY ROLE OF Vα14 NKT CELLS IN INNATE AND ACQUIRED IMMUNE RESPONSE |
| DOI | 10.1146/annurev.immunol.21.120601.141057 |
| Print ISSN | 0732-0582 |
| Журнал | Annual Review of Immunology |
| Том | 21 |
| Первая страница | 483 |
| Последняя страница | 513 |
| Аффилиация | Taniguchi, Masaru; Laboratory of Immune Regulation, RIKEN Research Center for Allergy and Immunology, and Department of Molecular Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan; email: taniguti@med.m.chiba-u.ac.jp harada@med.m.chiba-u.ac.jp skojo@med.m.chiba-u.ac.jp nakayama@med.m.chiba-u.ac.jp hwakao@med.m.chiba-u.ac.jp |
