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Genome sequence of the Brown Norway rat yields insights into mammalian evolution

Gibbs (Co-principal Investigator), Richard A.; Weinstock (Principal Investigator), George M.; Metzker, Michael L.; Muzny, Donna M.; Sodergren, Erica J.; Scherer, Steven; Scott, Graham; Steffen, David; Worley, Kim C.; Burch, Paula E.; Okwuonu, Geoffrey; Hines, Sandra; Lewis, Lora; DeRamo, Christine; Delgado, Oliver; Dugan-Rocha, Shannon; Miner, George; Morgan, Margaret; Hawes, Alicia; Gill, Rachel; Holt (Principal Investigator), Robert A.; Adams, Mark D.; Amanatides, Peter G.; Baden-Tillson, Holly; Barnstead, Mary; Chin, Soo; Evans, Cheryl A.; Ferriera, Steve; Fosler, Carl; Glodek, Anna; Gu, Zhiping; Jennings, Don; Kraft, Cheryl L.; Nguyen, Trixie; Pfannkoch, Cynthia M.; Sitter, Cynthia; Sutton, Granger G.; Venter, J. Craig; Woodage, Trevor; Smith (Principal Investigator), Douglas; Lee, Hong-Mei; Gustafson, Erik; Cahill, Patrick; Kana, Arnold; Doucette-Stamm, Lynn; Weinstock, Keith; Fechtel, Kim; Weiss (Principal Investigator), Robert B.; Dunn, Diane M.; Green, Eric D.; Blakesley, Robert W.; Bouffard, Gerard G.; de Jong (Principal Investigator), Pieter J.; Osoegawa, Kazutoyo; Zhu, Baoli; Marra (Principal Investigator), Marco; Schein (Principal Investigator), Jacqueline; Bosdet, Ian; Fjell, Chris; Jones, Steven; Krzywinski, Martin; Mathewson, Carrie; Siddiqui, Asim; Wye, Natasja; McPherson, John; Zhao (Principal Investigator), Shaying; Fraser, Claire M.; Shetty, Jyoti; Shatsman, Sofiya; Geer, Keita; Chen, Yixin; Abramzon, Sofyia; Nierman, William C.; Gibbs (Principal Investigator), Richard A.; Weinstock (Principal Investigator), George M.; Havlak, Paul H.; Chen, Rui; James Durbin, K.; Egan, Amy; Ren, Yanru; Song, Xing-Zhi; Li, Bingshan; Liu, Yue; Qin, Xiang; Cawley, Simon; Weinstock (Coordinator), George M.; Worley (Overall Coordinator), Kim C.; Cooney, A. J.; Gibbs, Richard A.; D'Souza, Lisa M.; Martin, Kirt; Qian Wu, Jia; Gonzalez-Garay, Manuel L.; Jackson, Andrew R.; Kalafus, Kenneth J.; McLeod, Michael P.; Milosavljevic, Aleksandar; Virk, Davinder; Volkov, Andrei; Wheeler, David A.; Zhang, Zhengdong; Bailey, Jeffrey A.; Eichler, Evan E.; Tuzun, Eray; Birney, Ewan; Mongin, Emmanuel; Ureta-Vidal, Abel; Woodwark, Cara; Zdobnov, Evgeny; Bork, Peer; Suyama, Mikita; Torrents, David; Alexandersson, Marina; Trask, Barbara J.; Young, Janet M.; Smith (Principal Investigator), Douglas; Huang, Hui; Fechtel, Kim; Wang, Huajun; Xing, Heming; Weinstock, Keith; Daniels, Sue; Gietzen, Darryl; Schmidt, Jeanette; Stevens, Kristian; Vitt, Ursula; Wingrove, Jim; Camara, Francisco; Mar Albà, M.; Abril, Josep F.; Guigo, Roderic; Smit, Arian; Dubchak, Inna; Rubin, Edward M.; Couronne, Olivier; Poliakov, Alexander; Hübner, Norbert; Ganten, Detlev; Goesele, Claudia; Hummel, Oliver; Kreitler, Thomas; Lee, Young-Ae; Monti, Jan; Schulz, Herbert; Zimdahl, Heike; Himmelbauer, Heinz; Lehrach, Hans; Jacob (Principal Investigator), Howard J.; Bromberg, Susan; Gullings-Handley, Jo; Jensen-Seaman, Michael I.; Kwitek, Anne E.; Lazar, Jozef; Pasko, Dean; Tonellato, Peter J.; Twigger, Simon; Ponting (Leader, Genes and Proteins Analysis Group), Chris P.; Duarte, Jose M.; Rice, Stephen; Goodstadt, Leo; Beatson, Scott A.; Emes, Richard D.; Winter, Eitan E.; Webber, Caleb; Brandt, Petra; Nyakatura, Gerald; Adetobi, Margaret; Chiaromonte, Francesca; Elnitski, Laura; Eswara, Pallavi; Hardison, Ross C.; Hou, Minmei; Kolbe, Diana; Makova, Kateryna; Miller, Webb; Nekrutenko, Anton; Riemer, Cathy; Schwartz, Scott; Taylor, James; Yang, Shan; Zhang, Yi; Lindpaintner, Klaus; Andrews, T. Dan; Caccamo, Mario; Clamp, Michele; Clarke, Laura; Curwen, Valerie; Durbin, Richard; Eyras, Eduardo; Searle, Stephen M.; Cooper (Co-Leader, Evolutionary Analysis Group), Gregory M.; Batzoglou, Serafim; Brudno, Michael; Sidow, Arend; Stone, Eric A.; Craig Venter, J.; Payseur, Bret A.; Bourque, Guillaume; López-Otín, Carlos; Puente, Xose S.; Chakrabarti, Kushal; Chatterji, Sourav; Dewey, Colin; Pachter, Lior; Bray, Nicolas; Yap, Von Bing; Caspi, Anat; Tesler, Glenn; Pevzner, Pavel A.; Haussler (Co-Leader, Evolutionary Analysis Group), David; Roskin, Krishna M.; Baertsch, Robert; Clawson, Hiram; Furey, Terrence S.; Hinrichs, Angie S.; Karolchik, Donna; Kent, William J.; Rosenbloom, Kate R.; Trumbower, Heather; Weirauch, Matt; Cooper, David N.; Stenson, Peter D.; Ma, Bin; Brent, Michael; Arumugam, Manimozhiyan; Shteynberg, David; Copley, Richard R.; Taylor, Martin S.; Riethman, Harold; Mudunuri, Uma; Peterson, Jane; Guyer, Mark; Felsenfeld, Adam; Old, Susan; Mockrin, Stephen; Collins, Francis; Rat Genome Sequencing Project Consortium; (Participants are arranged under area of contribution, and then by institution.); DNA sequencing: Baylor College of Medicine; Genome Therapeutics; University of Utah; NISC Comparative Sequencing Program, NHGRI; BAC library production: Children's Hospital Oakland Research Institute; BAC fingerprinting: British Columbia Cancer Agency, Canada's Michael Smith Genome Sciences Centre; Genome Sequencing Center, Washington University School of Medicine; BAC end sequencing: TIGR; Sequence assembly: Baylor College of Medicine; Analysis and annotation: Affymetrix; Baylor College of Medicine; Case Western Reserve University; EBI, Wellcome Trust Genome Campus; EMBL, Heidelberg; Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg; Fred Hutchinson Cancer Research Center; Genome Therapeutics; Incyte Corporation; Institut Municipal d'Investigacio Medica, Barcelona>; The Institute for Systems Biology; Lawrence Berkeley National Laboratory; Max Delbrück Center for Molecular Medicine; Max Planck Institute for Molecular Genetics, Berlin; Medical College of Wisconsin; MRC Functional Genetics Unit, University of Oxford; MWG-Biotech; Pennsylvania State University; Roche Genetics and Roche Center for Medical Genomics; Sanger Institute; Stanford University; The Center for the Advancement of Genomics; University of Arizona; Université de Montréal; Universidad de Oviedo; University of California, Berkeley; University of California, San Diego; University of California, Santa Cruz; University of Wales College of Medicine; University of Western Ontario; Washington University; Wellcome Trust Centre for Human Genetics, University of Oxford; The Wistar Institute; Scientific management:
Журнал: Nature
Дата: 2004

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Аннотация:

The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality â draftâ covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.
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