Durbin, Richard M.; Altshuler, David; Durbin, Richard M.; Abecasis, Gonçalo R.; Bentley, David R.; Chakravarti, Aravinda; Clark, Andrew G.; Collins, Francis S.; De La Vega, Francisco M.; Donnelly, Peter; Egholm, Michael; Flicek, Paul; Gabriel, Stacey B.; Gibbs, Richard A.; Knoppers, Bartha M.; Lander, Eric S.; Lehrach, Hans; Mardis, Elaine R.; McVean, Gil A.; Nickerson, Deborah A.; Peltonen, Leena; Schafer, Alan J.; Sherry, Stephen T.; Wang, Jun; Wilson, Richard K.; Gibbs, Richard A.; Deiros, David; Metzker, Mike; Muzny, Donna; Reid, Jeff; Wheeler, David; Wang, Jun; Li, Jingxiang; Jian, Min; Li, Guoqing; Li, Ruiqiang; Liang, Huiqing; Tian, Geng; Wang, Bo; Wang, Jian; Wang, Wei; Yang, Huanming; Zhang, Xiuqing; Zheng, Huisong; Lander, Eric S.; Altshuler, David; Ambrogio, Lauren; Bloom, Toby; Cibulskis, Kristian; Fennell, Tim J.; Gabriel, Stacey B.; Jaffe, David B.; Shefler, Erica; Sougnez, Carrie L.; Bentley, David R.; Gormley, Niall; Humphray, Sean; Kingsbury, Zoya; Kokko-Gonzales, Paula; Stone, Jennifer; McKernan, Kevin J.; Costa, Gina L.; Ichikawa, Jeffry K.; Lee, Clarence C.; Sudbrak, Ralf; Lehrach, Hans; Borodina, Tatiana A.; Dahl, Andreas; Davydov, Alexey N.; Marquardt, Peter; Mertes, Florian; Nietfeld, Wilfiried; Rosenstiel, Philip; Schreiber, Stefan; Soldatov, Aleksey V.; Timmermann, Bernd; Tolzmann, Marius; Egholm, Michael; Affourtit, Jason; Ashworth, Dana; Attiya, Said; Bachorski, Melissa; Buglione, Eli; Burke, Adam; Caprio, Amanda; Celone, Christopher; Clark, Shauna; Conners, David; Desany, Brian; Gu, Lisa; Guccione, Lorri; Kao, Kalvin; Kebbel, Andrew; Knowlton, Jennifer; Labrecque, Matthew; McDade, Louise; Mealmaker, Craig; Minderman, Melissa; Nawrocki, Anne; Niazi, Faheem; Pareja, Kristen; Ramenani, Ravi; Riches, David; Song, Wanmin; Turcotte, Cynthia; Wang, Shally; Mardis, Elaine R.; Wilson, Richard K.; Dooling, David; Fulton, Lucinda; Fulton, Robert; Weinstock, George; Durbin, Richard M.; Burton, John; Carter, David M.; Churcher, Carol; Coffey, Alison; Cox, Anthony; Palotie, Aarno; Quail, Michael; Skelly, Tom; Stalker, James; Swerdlow, Harold P.; Turner, Daniel; De Witte, Anniek; Giles, Shane; Gibbs, Richard A.; Wheeler, David; Bainbridge, Matthew; Challis, Danny; Sabo, Aniko; Yu, Fuli; Yu, Jin; Wang, Jun; Fang, Xiaodong; Guo, Xiaosen; Li, Ruiqiang; Li, Yingrui; Luo, Ruibang; Tai, Shuaishuai; Wu, Honglong; Zheng, Hancheng; Zheng, Xiaole; Zhou, Yan; Li, Guoqing; Wang, Jian; Yang, Huanming; Marth, Gabor T.; Garrison, Erik P.; Huang, Weichun; Indap, Amit; Kural, Deniz; Lee, Wan-Ping; Fung Leong, Wen; Quinlan, Aaron R.; Stewart, Chip; Stromberg, Michael P.; Ward, Alistair N.; Wu, Jiantao; Lee, Charles; Mills, Ryan E.; Shi, Xinghua; Daly, Mark J.; DePristo, Mark A.; Altshuler, David; Ball, Aaron D.; Banks, Eric; Bloom, Toby; Browning, Brian L.; Cibulskis, Kristian; Fennell, Tim J.; Garimella, Kiran V.; Grossman, Sharon R.; Handsaker, Robert E.; Hanna, Matt; Hartl, Chris; Jaffe, David B.; Kernytsky, Andrew M.; Korn, Joshua M.; Li, Heng; Maguire, Jared R.; McCarroll, Steven A.; McKenna, Aaron; Nemesh, James C.; Philippakis, Anthony A.; Poplin, Ryan E.; Price, Alkes; Rivas, Manuel A.; Sabeti, Pardis C.; Schaffner, Stephen F.; Shefler, Erica; Shlyakhter, Ilya A.; Cooper, David N.; Ball, Edward V.; Mort, Matthew; Phillips, Andrew D.; Stenson, Peter D.; Sebat, Jonathan; Makarov, Vladimir; Ye, Kenny; Yoon, Seungtai C.; Bustamante, Carlos D.; Clarke, Laura; Flicek, Paul; Cunningham, Fiona; Herrero, Javier; Keenen, Stephen; Kulesha, Eugene; Leinonen, Rasko; McLaren, William M.; Radhakrishnan, Rajesh; Smith, Richard E.; Zalunin, Vadim; Zheng-Bradley, Xiangqun; Korbel, Jan O.; Stütz, Adrian M.; Humphray, Sean; Bauer, Markus; Keira Cheetham, R.; Cox, Tony; Eberle, Michael; James, Terena; Kahn, Scott; Murray, Lisa; Chakravarti, Aravinda; Ye, Kai; De La Vega, Francisco M.; Fu, Yutao; Hyland, Fiona C. L.; Manning, Jonathan M.; McLaughlin, Stephen F.; Peckham, Heather E.; Sakarya, Onur; Sun, Yongming A.; Tsung, Eric F.; Batzer, Mark A.; Konkel, Miriam K.; Walker, Jerilyn A.; Sudbrak, Ralf; Albrecht, Marcus W.; Amstislavskiy, Vyacheslav S.; Herwig, Ralf; Parkhomchuk, Dimitri V.; Sherry, Stephen T.; Agarwala, Richa; Khouri, Hoda M.; Morgulis, Aleksandr O.; Paschall, Justin E.; Phan, Lon D.; Rotmistrovsky, Kirill E.; Sanders, Robert D.; Shumway, Martin F.; Xiao, Chunlin; McVean, Gil A.; Auton, Adam; Iqbal, Zamin; Lunter, Gerton; Marchini, Jonathan L.; Moutsianas, Loukas; Myers, Simon; Tumian, Afidalina; Desany, Brian; Knight, James; Winer, Roger; Craig, David W.; Beckstrom-Sternberg, Steve M.; Christoforides, Alexis; Kurdoglu, Ahmet A.; Pearson, John V.; Sinari, Shripad A.; Tembe, Waibhav D.; Haussler, David; Hinrichs, Angie S.; Katzman, Sol J.; Kern, Andrew; Kuhn, Robert M.; Przeworski, Molly; Hernandez, Ryan D.; Howie, Bryan; Kelley, Joanna L.; Cord Melton, S.; Abecasis, Gonçalo R.; Li, Yun; Anderson, Paul; Blackwell, Tom; Chen, Wei; Cookson, William O.; Ding, Jun; Min Kang, Hyun; Lathrop, Mark; Liang, Liming; Moffatt, Miriam F.; Scheet, Paul; Sidore, Carlo; Snyder, Matthew; Zhan, Xiaowei; Zöllner, Sebastian; Awadalla, Philip; Cartwright, Reed A.; Casals, Ferran; Idaghdour, Youssef; Keebler, Jonathan; Stone, Eric A.; Zilversmit, Martine; Jorde, Lynn; Xing, Jinchuan; Eichler, Evan E.; Aksay, Gozde; Alkan, Can; Hajirasouliha, Iman; Mardis, Elaine R.; Chen, Ken; Chinwalla, Asif; Ding, Li; Koboldt, Daniel C.; McLellan, Mike D.; Dooling, David; Weinstock, George; Wallis, John W.; Wendl, Michael C.; Zhang, Qunyuan; Durbin, Richard M.; Albers, Cornelis A.; Ayub, Qasim; Balasubramaniam, Senduran; Barrett, Jeffrey C.; Carter, David M.; Chen, Yuan; Conrad, Donald F.; Danecek, Petr; Dermitzakis, Emmanouil T.; Hu, Min; Huang, Ni; Hurles, Matt E.; Jin, Hanjun; Jostins, Luke; Keane, Thomas M.; Quang Le, Si; Lindsay, Sarah; Long, Quan; MacArthur, Daniel G.; Montgomery, Stephen B.; Parts, Leopold; Stalker, James; Tyler-Smith, Chris; Walter, Klaudia; Xue, Yali; Zhang, Yujun; Gerstein, Mark B.; Snyder, Michael; Abyzov, Alexej; Balasubramanian, Suganthi; Bjornson, Robert; Du, Jiang; Grubert, Fabian; Habegger, Lukas; Haraksingh, Rajini; Jee, Justin; Khurana, Ekta; Lam, Hugo Y. K.; Leng, Jing; Jasmine Mu, Xinmeng; Urban, Alexander E.; Zhang, Zhengdong; Li, Yingrui; Luo, Ruibang; Marth, Gabor T.; Garrison, Erik P.; Kural, Deniz; Quinlan, Aaron R.; Stewart, Chip; Stromberg, Michael P.; Ward, Alistair N.; Wu, Jiantao; Lee, Charles; Mills, Ryan E.; Shi, Xinghua; McCarroll, Steven A.; Banks, Eric; DePristo, Mark A.; Handsaker, Robert E.; Hartl, Chris; Korn, Joshua M.; Li, Heng; Nemesh, James C.; Sebat, Jonathan; Makarov, Vladimir; Ye, Kenny; Yoon, Seungtai C.; Degenhardt, Jeremiah; Kaganovich, Mark; Clarke, Laura; Smith, Richard E.; Zheng-Bradley, Xiangqun; Korbel, Jan O.; Humphray, Sean; Keira Cheetham, R.; Eberle, Michael; Kahn, Scott; Murray, Lisa; Ye, Kai; De La Vega, Francisco M.; Fu, Yutao; Peckham, Heather E.; Sun, Yongming A.; Batzer, Mark A.; Konkel, Miriam K.; Walker, Jerilyn A.; Xiao, Chunlin; Iqbal, Zamin; Desany, Brian; Blackwell, Tom; Snyder, Matthew; Xing, Jinchuan; Eichler, Evan E.; Aksay, Gozde; Alkan, Can; Hajirasouliha, Iman; Hormozdiari, Fereydoun; Kidd, Jeffrey M.; Chen, Ken; Chinwalla, Asif; Ding, Li; McLellan, Mike D.; Wallis, John W.; Hurles, Matt E.; Conrad, Donald F.; Walter, Klaudia; Zhang, Yujun; Gerstein, Mark B.; Snyder, Michael; Abyzov, Alexej; Du, Jiang; Grubert, Fabian; Haraksingh, Rajini; Jee, Justin; Khurana, Ekta; Lam, Hugo Y. K.; Leng, Jing; Jasmine Mu, Xinmeng; Urban, Alexander E.; Zhang, Zhengdong; Gibbs, Richard A.; Bainbridge, Matthew; Challis, Danny; Coafra, Cristian; Dinh, Huyen; Kovar, Christie; Lee, Sandy; Muzny, Donna; Nazareth, Lynne; Reid, Jeff; Sabo, Aniko; Yu, Fuli; Yu, Jin; Marth, Gabor T.; Garrison, Erik P.; Indap, Amit; Fung Leong, Wen; Quinlan, Aaron R.; Stewart, Chip; Ward, Alistair N.; Wu, Jiantao; Cibulskis, Kristian; Fennell, Tim J.; Gabriel, Stacey B.; Garimella, Kiran V.; Hartl, Chris; Shefler, Erica; Sougnez, Carrie L.; Wilkinson, Jane; Clark, Andrew G.; Gravel, Simon; Grubert, Fabian; Clarke, Laura; Flicek, Paul; Smith, Richard E.; Zheng-Bradley, Xiangqun; Sherry, Stephen T.; Khouri, Hoda M.; Paschall, Justin E.; Shumway, Martin F.; Xiao, Chunlin; McVean, Gil A.; Katzman, Sol J.; Abecasis, Gonçalo R.; Blackwell, Tom; Mardis, Elaine R.; Dooling, David; Fulton, Lucinda; Fulton, Robert; Koboldt, Daniel C.; Durbin, Richard M.; Balasubramaniam, Senduran; Coffey, Allison; Keane, Thomas M.; MacArthur, Daniel G.; Palotie, Aarno; Scott, Carol; Stalker, James; Tyler-Smith, Chris; Gerstein, Mark B.; Balasubramanian, Suganthi; Chakravarti, Aravinda; Knoppers, Bartha M.; Peltonen, Leena; Abecasis, Gonçalo R.; Bustamante, Carlos D.; Gharani, Neda; Gibbs, Richard A.; Jorde, Lynn; Kaye, Jane S.; Kent, Alastair; Li, Taosha; McGuire, Amy L.; McVean, Gil A.; Ossorio, Pilar N.; Rotimi, Charles N.; Su, Yeyang; Toji, Lorraine H.; Tyler-Smith, Chris; Brooks, Lisa D.; Felsenfeld, Adam L.; McEwen, Jean E.; Abdallah, Assya; Juenger, Christopher R.; Clemm, Nicholas C.; Collins, Francis S.; Duncanson, Audrey; Green, Eric D.; Guyer, Mark S.; Peterson, Jane L.; Schafer, Alan J.; Abecasis, Gonçalo R.; Altshuler, David; Auton, Adam; Brooks, Lisa D.; Durbin, Richard M.; Gibbs, Richard A.; Hurles, Matt E.; McVean, Gil A.; The 1000 Genomes Project Consortium; Corresponding author; Steering committee; Production group: Baylor College of Medicine; BGI-Shenzhen; Broad Institute of MIT and Harvard; Illumina; Life Technologies; Max Planck Institute for Molecular Genetics; Roche Applied Science; Washington University in St Louis; Wellcome Trust Sanger Institute; Analysis group: Agilent Technologies; Baylor College of Medicine; BGI-Shenzhen; Boston College; Brigham and Womenâ s Hospital; Broad Institute of MIT and Harvard; Cardiff University, The Human Gene Mutation Database; Cold Spring Harbor Laboratory; Cornell and Stanford Universities; European Bioinformatics Institute; European Molecular Biology Laboratory; Illumina; Johns Hopkins University; Leiden University Medical Center; Life Technologies; Louisiana State University; Max Planck Institute for Molecular Genetics; US National Institutes of Health; Oxford University; Roche Applied Science; The Translational Genomics Research Institute; University of California, Santa Cruz; University of Chicago; University of Michigan; University of Montreal; University of Utah; University of Washington; Washington University in St Louis; Wellcome Trust Sanger Institute; Yale and Stanford Universities; Structural variation group: BGI-Shenzhen; Boston College; Brigham and Womenâ s Hospital; Broad Institute of MIT and Harvard; Cold Spring Harbor Laboratory; Cornell and Stanford Universities; European Bioinformatics Institute; European Molecular Biology Laboratory; Illumina; Leiden University Medical Center; Life Technologies; Louisiana State University; US National Institutes of Health; Oxford University; Roche Applied Science; University of Michigan; University of Utah; University of Washington; Washington University in St Louis; Wellcome Trust Sanger Institute; Yale and Stanford Universities; Exon pilot group: Baylor College of Medicine; Boston College; Broad Institute of MIT and Harvard; Cornell and Stanford Universities; European Bioinformatics Institute; US National Institutes of Health; Oxford University; University of California, Santa Cruz; University of Michigan; Washington University in St Louis; Wellcome Trust Sanger Institute; Yale University; Samples and ELSI group; Scientific management; Writing group; Durbin, Richard M.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Altshuler, David; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Durbin, Richard M.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Abecasis, Gonçalo R.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Bentley, David R.; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; Chakravarti, Aravinda; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Clark, Andrew G.; Center for Comparative and Population Genomics, Cornell University, Ithaca, New York 14850, USA.; Collins, Francis S.; US National Institutes of Health, 1 Center Drive, Bethesda, Maryland 20892, USA.; De La Vega, Francisco M.; Life Technologies, Foster City, California 94404, USA.; Donnelly, Peter; Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.; Egholm, Michael; Pall Corporation, 25 Harbor Park Drive, Port Washington, New York 11050, USA.; Flicek, Paul; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Gabriel, Stacey B.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Gibbs, Richard A.; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Knoppers, Bartha M.; Centre of Genomics and Policy, McGill University, Montréal, Québec H3A 1A4, Canada.; Lander, Eric S.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Lehrach, Hans; Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany.; Mardis, Elaine R.; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; McVean, Gil A.; Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.; Nickerson, Deborah A.; Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA.; Peltonen, Leena; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Schafer, Alan J.; Wellcome Trust, Gibbs Building, 215 Euston Road, London NW1 2BE, UK.; Sherry, Stephen T.; US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA.; Wang, Jun; BGI-Shenzhen, Shenzhen 518083, China.; Department of Biology, University of Copenhagen 2200, Denmark.; Wilson, Richard K.; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Gibbs, Richard A.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Deiros, David; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Metzker, Mike; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Muzny, Donna; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Reid, Jeff; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Wheeler, David; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Wang, Jun; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Li, Jingxiang; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Jian, Min; BGI-Shenzhen, Shenzhen 518083, China.; Li, Guoqing; BGI-Shenzhen, Shenzhen 518083, China.; Li, Ruiqiang; BGI-Shenzhen, Shenzhen 518083, China.; Department of Biology, University of Copenhagen 2200, Denmark.; Liang, Huiqing; BGI-Shenzhen, Shenzhen 518083, China.; Tian, Geng; BGI-Shenzhen, Shenzhen 518083, China.; Wang, Bo; BGI-Shenzhen, Shenzhen 518083, China.; Wang, Jian; BGI-Shenzhen, Shenzhen 518083, China.; Wang, Wei; BGI-Shenzhen, Shenzhen 518083, China.; Yang, Huanming; BGI-Shenzhen, Shenzhen 518083, China.; Zhang, Xiuqing; BGI-Shenzhen, Shenzhen 518083, China.; Zheng, Huisong; BGI-Shenzhen, Shenzhen 518083, China.; Lander, Eric S.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Altshuler, David; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Department of Genetics, Harvard Medical School, Cambridge, Massachusetts 02115, USA.; Ambrogio, Lauren; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Bloom, Toby; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Cibulskis, Kristian; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Fennell, Tim J.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Gabriel, Stacey B.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Jaffe, David B.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Shefler, Erica; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Sougnez, Carrie L.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Bentley, David R.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Gormley, Niall; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; Humphray, Sean; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; Kingsbury, Zoya; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; Kokko-Gonzales, Paula; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; Stone, Jennifer; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; McKernan, Kevin J.; Life Technologies, Beverly, Massachusetts 01915, USA.; Costa, Gina L.; Life Technologies, Beverly, Massachusetts 01915, USA.; Ichikawa, Jeffry K.; Life Technologies, Beverly, Massachusetts 01915, USA.; Lee, Clarence C.; Life Technologies, Beverly, Massachusetts 01915, USA.; Sudbrak, Ralf; Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany.; Lehrach, Hans; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Borodina, Tatiana A.; Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany.; Dahl, Andreas; Deep Sequencing Group, Biotechnology Center TU Dresden, Tatzberg 47/49, 01307 Dresden, Germany.; Davydov, Alexey N.; Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany.; Marquardt, Peter; Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany.; Mertes, Florian; Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany.; Nietfeld, Wilfiried; Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany.; Rosenstiel, Philip; Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel 24105, Germany.; Schreiber, Stefan; Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel 24105, Germany.; Soldatov, Aleksey V.; Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany.; Timmermann, Bernd; Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany.; Tolzmann, Marius; Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany.; Egholm, Michael; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Affourtit, Jason; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Ashworth, Dana; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Attiya, Said; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Bachorski, Melissa; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Buglione, Eli; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Burke, Adam; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Caprio, Amanda; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Celone, Christopher; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Clark, Shauna; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Conners, David; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Desany, Brian; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Gu, Lisa; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Guccione, Lorri; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Kao, Kalvin; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Kebbel, Andrew; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Knowlton, Jennifer; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Labrecque, Matthew; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; McDade, Louise; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Mealmaker, Craig; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Minderman, Melissa; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Nawrocki, Anne; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Niazi, Faheem; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Pareja, Kristen; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Ramenani, Ravi; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Riches, David; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Song, Wanmin; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Turcotte, Cynthia; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Wang, Shally; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Mardis, Elaine R.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Wilson, Richard K.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Dooling, David; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Fulton, Lucinda; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Fulton, Robert; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Weinstock, George; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Durbin, Richard M.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Burton, John; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Carter, David M.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Churcher, Carol; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Coffey, Alison; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Cox, Anthony; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Palotie, Aarno; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Department of Medical Genetics, Institute of Molecular Medicine (FIMM) of the University of Helsinki and Helsinki University Hospital, Helsinki 00290, Finland.; Quail, Michael; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Skelly, Tom; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Stalker, James; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Swerdlow, Harold P.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Turner, Daniel; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; De Witte, Anniek; Agilent Technologies Inc., Santa Clara, California 95051, USA.; Giles, Shane; Agilent Technologies Inc., Santa Clara, California 95051, USA.; Gibbs, Richard A.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Wheeler, David; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Bainbridge, Matthew; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Challis, Danny; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Sabo, Aniko; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Yu, Fuli; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Yu, Jin; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Wang, Jun; BGI-Shenzhen, Shenzhen 518083, China.; Fang, Xiaodong; BGI-Shenzhen, Shenzhen 518083, China.; Guo, Xiaosen; BGI-Shenzhen, Shenzhen 518083, China.; Li, Ruiqiang; BGI-Shenzhen, Shenzhen 518083, China.; Department of Biology, University of Copenhagen 2200, Denmark.; Li, Yingrui; BGI-Shenzhen, Shenzhen 518083, China.; Luo, Ruibang; BGI-Shenzhen, Shenzhen 518083, China.; Tai, Shuaishuai; BGI-Shenzhen, Shenzhen 518083, China.; Wu, Honglong; BGI-Shenzhen, Shenzhen 518083, China.; Zheng, Hancheng; BGI-Shenzhen, Shenzhen 518083, China.; Zheng, Xiaole; BGI-Shenzhen, Shenzhen 518083, China.; Zhou, Yan; BGI-Shenzhen, Shenzhen 518083, China.; Li, Guoqing; BGI-Shenzhen, Shenzhen 518083, China.; Wang, Jian; BGI-Shenzhen, Shenzhen 518083, China.; Yang, Huanming; BGI-Shenzhen, Shenzhen 518083, China.; Marth, Gabor T.; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Garrison, Erik P.; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Huang, Weichun; US National Institutes of Health, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, North Carolina 27709, USA.; Indap, Amit; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Kural, Deniz; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Lee, Wan-Ping; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Fung Leong, Wen; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Quinlan, Aaron R.; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.; Stewart, Chip; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Stromberg, Michael P.; Illumina, San Diego, California 92121, USA.; Ward, Alistair N.; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Wu, Jiantao; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Lee, Charles; Department of Pathology, Brigham and Womenâ s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Mills, Ryan E.; Department of Pathology, Brigham and Womenâ s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Shi, Xinghua; Department of Pathology, Brigham and Womenâ s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Daly, Mark J.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; DePristo, Mark A.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Altshuler, David; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Department of Pathology, Brigham and Womenâ s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Ball, Aaron D.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Banks, Eric; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Bloom, Toby; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Browning, Brian L.; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington 98195, USA.; Cibulskis, Kristian; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Fennell, Tim J.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Garimella, Kiran V.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Grossman, Sharon R.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Handsaker, Robert E.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Hanna, Matt; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Hartl, Chris; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Jaffe, David B.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Kernytsky, Andrew M.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Korn, Joshua M.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Li, Heng; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Maguire, Jared R.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; McCarroll, Steven A.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Cambridge, Massachusetts 02115, USA.; McKenna, Aaron; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Nemesh, James C.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Philippakis, Anthony A.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Poplin, Ryan E.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Price, Alkes; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Rivas, Manuel A.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Sabeti, Pardis C.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Schaffner, Stephen F.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Shefler, Erica; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Shlyakhter, Ilya A.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Cooper, David N.; Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.; Ball, Edward V.; Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.; Mort, Matthew; Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.; Phillips, Andrew D.; Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.; Stenson, Peter D.; Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.; Sebat, Jonathan; Departments of Psychiatry and Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.; Makarov, Vladimir; Seaver Autism Center and Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.; Ye, Kenny; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA.; Yoon, Seungtai C.; Seaver Autism Center and Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.; Bustamante, Carlos D.; Department of Genetics, Stanford University, Stanford, California 94305, USA.; Clarke, Laura; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Flicek, Paul; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Cunningham, Fiona; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Herrero, Javier; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Keenen, Stephen; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Kulesha, Eugene; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Leinonen, Rasko; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; McLaren, William M.; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Radhakrishnan, Rajesh; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Smith, Richard E.; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Zalunin, Vadim; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Zheng-Bradley, Xiangqun; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Korbel, Jan O.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Stütz, Adrian M.; European Molecular Biology Laboratory, Genome Biology Research Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany.; Humphray, Sean; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Bauer, Markus; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Keira Cheetham, R.; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; Cox, Tony; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; Eberle, Michael; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; James, Terena; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; Kahn, Scott; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; Murray, Lisa; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; Chakravarti, Aravinda; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Ye, Kai; Molecular Epidemiology Section, Medical Statistics and Bioinformatics, Leiden University Medical Center, 2333 ZA, The Netherlands.; De La Vega, Francisco M.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Fu, Yutao; Life Technologies, Beverly, Massachusetts 01915, USA.; Hyland, Fiona C. L.; Life Technologies, Foster City, California 94404, USA.; Manning, Jonathan M.; Life Technologies, Beverly, Massachusetts 01915, USA.; McLaughlin, Stephen F.; Life Technologies, Beverly, Massachusetts 01915, USA.; Peckham, Heather E.; Life Technologies, Beverly, Massachusetts 01915, USA.; Sakarya, Onur; Life Technologies, Foster City, California 94404, USA.; Sun, Yongming A.; Life Technologies, Foster City, California 94404, USA.; Tsung, Eric F.; Life Technologies, Beverly, Massachusetts 01915, USA.; Batzer, Mark A.; Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA.; Konkel, Miriam K.; Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA.; Walker, Jerilyn A.; Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA.; Sudbrak, Ralf; Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany.; Albrecht, Marcus W.; Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany.; Amstislavskiy, Vyacheslav S.; Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany.; Herwig, Ralf; Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany.; Parkhomchuk, Dimitri V.; Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany.; Sherry, Stephen T.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Agarwala, Richa; US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA.; Khouri, Hoda M.; US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA.; Morgulis, Aleksandr O.; US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA.; Paschall, Justin E.; US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA.; Phan, Lon D.; US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA.; Rotmistrovsky, Kirill E.; US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA.; Sanders, Robert D.; US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA.; Shumway, Martin F.; US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA.; Xiao, Chunlin; US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA.; McVean, Gil A.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Auton, Adam; Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.; Iqbal, Zamin; Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.; Lunter, Gerton; Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.; Marchini, Jonathan L.; Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.; Department of Statistics, University of Oxford, Oxford OX1 3TG, UK.; Moutsianas, Loukas; Department of Statistics, University of Oxford, Oxford OX1 3TG, UK.; Myers, Simon; Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.; Department of Statistics, University of Oxford, Oxford OX1 3TG, UK.; Tumian, Afidalina; Department of Statistics, University of Oxford, Oxford OX1 3TG, UK.; Desany, Brian; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Knight, James; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Winer, Roger; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Craig, David W.; The Translational Genomics Research Institute, 445 N Fifth Street, Phoenix, Arizona 85004, USA.; Beckstrom-Sternberg, Steve M.; The Translational Genomics Research Institute, 445 N Fifth Street, Phoenix, Arizona 85004, USA.; Christoforides, Alexis; The Translational Genomics Research Institute, 445 N Fifth Street, Phoenix, Arizona 85004, USA.; Kurdoglu, Ahmet A.; The Translational Genomics Research Institute, 445 N Fifth Street, Phoenix, Arizona 85004, USA.; Pearson, John V.; The Translational Genomics Research Institute, 445 N Fifth Street, Phoenix, Arizona 85004, USA.; Sinari, Shripad A.; The Translational Genomics Research Institute, 445 N Fifth Street, Phoenix, Arizona 85004, USA.; Tembe, Waibhav D.; The Translational Genomics Research Institute, 445 N Fifth Street, Phoenix, Arizona 85004, USA.; Haussler, David; Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA.; Hinrichs, Angie S.; Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA.; Katzman, Sol J.; Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA.; Kern, Andrew; Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA.; Kuhn, Robert M.; Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA.; Przeworski, Molly; Department of Human Genetics and Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA.; Hernandez, Ryan D.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California 94158, USA.; Howie, Bryan; Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA.; Kelley, Joanna L.; Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA.; Cord Melton, S.; Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA.; Abecasis, Gonçalo R.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Li, Yun; Center for Statistical Genetics and Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Anderson, Paul; Center for Statistical Genetics and Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Blackwell, Tom; Center for Statistical Genetics and Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Chen, Wei; Center for Statistical Genetics and Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Cookson, William O.; National Heart and Lung Institute, Imperial College London, London SW7 2, UK.; Ding, Jun; Center for Statistical Genetics and Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Min Kang, Hyun; Center for Statistical Genetics and Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Lathrop, Mark; Centre Nationale de Génotypage, Evry 91000, France.; Liang, Liming; Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Moffatt, Miriam F.; National Heart and Lung Institute, Imperial College London, London SW7 2, UK.; Scheet, Paul; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.; Sidore, Carlo; Center for Statistical Genetics and Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Snyder, Matthew; Center for Statistical Genetics and Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Zhan, Xiaowei; Center for Statistical Genetics and Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Zöllner, Sebastian; Center for Statistical Genetics and Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Awadalla, Philip; Department of Pediatrics, Faculty of Medicine, University of Montréal, Ste. Justine Hospital Research Centre, Montréal, Québec H3T 1C5, Canada.; Cartwright, Reed A.; Department of Ecology and Evolutionary Biology, Rice University, Houston, Texas 77251, USA.; Casals, Ferran; Department of Medicine, Centre Hospitalier de lâ Université de Montréal Research Center, Université de Montréal, Montréal, Québec H2L 2W5, Canada.; Idaghdour, Youssef; Department of Medicine, Centre Hospitalier de lâ Université de Montréal Research Center, Université de Montréal, Montréal, Québec H2L 2W5, Canada.; Keebler, Jonathan; Department of Medicine, Centre Hospitalier de lâ Université de Montréal Research Center, Université de Montréal, Montréal, Québec H2L 2W5, Canada.; Stone, Eric A.; Department of Medicine, Centre Hospitalier de lâ Université de Montréal Research Center, Université de Montréal, Montréal, Québec H2L 2W5, Canada.; Zilversmit, Martine; Department of Medicine, Centre Hospitalier de lâ Université de Montréal Research Center, Université de Montréal, Montréal, Québec H2L 2W5, Canada.; Jorde, Lynn; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Xing, Jinchuan; Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.; Eichler, Evan E.; Department of Genome Sciences, University of Washington School of Medicine and Howard Hughes Medical Institute, Seattle, Washington 98195, USA.; Aksay, Gozde; Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA.; Alkan, Can; Department of Genome Sciences, University of Washington School of Medicine and Howard Hughes Medical Institute, Seattle, Washington 98195, USA.; Hajirasouliha, Iman; Department of Computer Science, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.; Mardis, Elaine R.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Chen, Ken; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Chinwalla, Asif; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Ding, Li; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Koboldt, Daniel C.; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; McLellan, Mike D.; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Dooling, David; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Weinstock, George; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Wallis, John W.; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Wendl, Michael C.; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Zhang, Qunyuan; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Durbin, Richard M.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Albers, Cornelis A.; Department of Haematology, University of Cambridge and National Health Service Blood and Transplant, Cambridge CB2 1TN, UK.; Ayub, Qasim; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Balasubramaniam, Senduran; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Barrett, Jeffrey C.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Carter, David M.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Chen, Yuan; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Conrad, Donald F.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Danecek, Petr; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Dermitzakis, Emmanouil T.; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva 1211, Switzerland.; Hu, Min; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Huang, Ni; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Hurles, Matt E.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Jin, Hanjun; Center for Genome Science, Korea National Institute of Health, 194, Tongil-Lo, Eunpyung-Gu, Seoul 122-701, Korea.; Jostins, Luke; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Keane, Thomas M.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Quang Le, Si; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Lindsay, Sarah; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Long, Quan; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; MacArthur, Daniel G.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Montgomery, Stephen B.; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva 1211, Switzerland.; Parts, Leopold; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Stalker, James; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Tyler-Smith, Chris; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Walter, Klaudia; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Xue, Yali; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Zhang, Yujun; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Gerstein, Mark B.; Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA.; Snyder, Michael; Department of Genetics, Stanford University, Stanford, California 94305, USA.; Abyzov, Alexej; Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA.; Balasubramanian, Suganthi; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA.; Bjornson, Robert; Department of Computer Science, Yale University, New Haven, Connecticut 06520, USA.; Du, Jiang; Department of Computer Science, Yale University, New Haven, Connecticut 06520, USA.; Grubert, Fabian; Department of Genetics, Stanford University, Stanford, California 94305, USA.; Habegger, Lukas; Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA.; Haraksingh, Rajini; Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA.; Jee, Justin; Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA.; Khurana, Ekta; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA.; Lam, Hugo Y. K.; Department of Genetics, Stanford University, Stanford, California 94305, USA.; Leng, Jing; Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA.; Jasmine Mu, Xinmeng; Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA.; Urban, Alexander E.; Department of Genetics, Stanford University, Stanford, California 94305, USA.; Department of Psychiatry and Behavioral Studies, Stanford University, Stanford, California 94305, USA.; Zhang, Zhengdong; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA.; Li, Yingrui; BGI-Shenzhen, Shenzhen 518083, China.; Luo, Ruibang; BGI-Shenzhen, Shenzhen 518083, China.; Marth, Gabor T.; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Garrison, Erik P.; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Kural, Deniz; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Quinlan, Aaron R.; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.; Stewart, Chip; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Stromberg, Michael P.; Illumina, San Diego, California 92121, USA.; Ward, Alistair N.; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Wu, Jiantao; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Lee, Charles; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Mills, Ryan E.; Department of Pathology, Brigham and Womenâ s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Shi, Xinghua; Department of Pathology, Brigham and Womenâ s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; McCarroll, Steven A.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Banks, Eric; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; DePristo, Mark A.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Handsaker, Robert E.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Hartl, Chris; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Korn, Joshua M.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Li, Heng; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Nemesh, James C.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Sebat, Jonathan; Departments of Psychiatry and Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.; Makarov, Vladimir; Seaver Autism Center and Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.; Ye, Kenny; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA.; Yoon, Seungtai C.; Seaver Autism Center and Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.; Degenhardt, Jeremiah; Center for Comparative and Population Genomics, Cornell University, Ithaca, New York 14850, USA.; Kaganovich, Mark; Department of Genetics, Stanford University, Stanford, California 94305, USA.; Clarke, Laura; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Smith, Richard E.; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Zheng-Bradley, Xiangqun; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Korbel, Jan O.; European Molecular Biology Laboratory, Genome Biology Research Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany.; Humphray, Sean; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Keira Cheetham, R.; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; Eberle, Michael; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; Kahn, Scott; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; Murray, Lisa; Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK.; Ye, Kai; Molecular Epidemiology Section, Medical Statistics and Bioinformatics, Leiden University Medical Center, 2333 ZA, The Netherlands.; De La Vega, Francisco M.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Fu, Yutao; Life Technologies, Beverly, Massachusetts 01915, USA.; Peckham, Heather E.; Life Technologies, Beverly, Massachusetts 01915, USA.; Sun, Yongming A.; Life Technologies, Foster City, California 94404, USA.; Batzer, Mark A.; Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA.; Konkel, Miriam K.; Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA.; Walker, Jerilyn A.; Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA.; Xiao, Chunlin; US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA.; Iqbal, Zamin; Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.; Desany, Brian; Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA.; Blackwell, Tom; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Snyder, Matthew; Center for Statistical Genetics and Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Xing, Jinchuan; Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.; Eichler, Evan E.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Aksay, Gozde; Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA.; Alkan, Can; Department of Genome Sciences, University of Washington School of Medicine and Howard Hughes Medical Institute, Seattle, Washington 98195, USA.; Hajirasouliha, Iman; Department of Computer Science, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.; Hormozdiari, Fereydoun; Department of Computer Science, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.; Kidd, Jeffrey M.; Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA.; Department of Genetics, Stanford University, Stanford, California 94305, USA.; Chen, Ken; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Chinwalla, Asif; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Ding, Li; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; McLellan, Mike D.; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Wallis, John W.; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Hurles, Matt E.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Conrad, Donald F.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Walter, Klaudia; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Zhang, Yujun; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Gerstein, Mark B.; Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA.; Snyder, Michael; Department of Genetics, Stanford University, Stanford, California 94305, USA.; Abyzov, Alexej; Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA.; Du, Jiang; Department of Computer Science, Yale University, New Haven, Connecticut 06520, USA.; Grubert, Fabian; Department of Genetics, Stanford University, Stanford, California 94305, USA.; Haraksingh, Rajini; Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA.; Jee, Justin; Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA.; Khurana, Ekta; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA.; Lam, Hugo Y. K.; Department of Genetics, Stanford University, Stanford, California 94305, USA.; Leng, Jing; Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA.; Jasmine Mu, Xinmeng; Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA.; Urban, Alexander E.; Department of Genetics, Stanford University, Stanford, California 94305, USA.; Department of Psychiatry and Behavioral Studies, Stanford University, Stanford, California 94305, USA.; Zhang, Zhengdong; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA.; Gibbs, Richard A.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Bainbridge, Matthew; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Challis, Danny; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Coafra, Cristian; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Dinh, Huyen; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Kovar, Christie; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Lee, Sandy; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Muzny, Donna; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Nazareth, Lynne; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Reid, Jeff; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Sabo, Aniko; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Yu, Fuli; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Yu, Jin; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Marth, Gabor T.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Garrison, Erik P.; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Indap, Amit; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Fung Leong, Wen; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Quinlan, Aaron R.; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.; Stewart, Chip; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Ward, Alistair N.; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Wu, Jiantao; Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.; Cibulskis, Kristian; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Fennell, Tim J.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Gabriel, Stacey B.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Garimella, Kiran V.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Hartl, Chris; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Shefler, Erica; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Sougnez, Carrie L.; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Wilkinson, Jane; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Clark, Andrew G.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Gravel, Simon; Department of Genetics, Stanford University, Stanford, California 94305, USA.; Grubert, Fabian; Department of Genetics, Stanford University, Stanford, California 94305, USA.; Clarke, Laura; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Flicek, Paul; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Smith, Richard E.; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Zheng-Bradley, Xiangqun; European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.; Sherry, Stephen T.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Khouri, Hoda M.; US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA.; Paschall, Justin E.; US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA.; Shumway, Martin F.; US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA.; Xiao, Chunlin; US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA.; McVean, Gil A.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Katzman, Sol J.; Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA.; Abecasis, Gonçalo R.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Blackwell, Tom; Center for Statistical Genetics and Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Mardis, Elaine R.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Dooling, David; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Fulton, Lucinda; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Fulton, Robert; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Koboldt, Daniel C.; The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Durbin, Richard M.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Balasubramaniam, Senduran; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Coffey, Allison; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Keane, Thomas M.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; MacArthur, Daniel G.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Palotie, Aarno; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Department of Medical Genetics, Institute of Molecular Medicine (FIMM) of the University of Helsinki and Helsinki University Hospital, Helsinki 00290, Finland.; Scott, Carol; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Stalker, James; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Tyler-Smith, Chris; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Gerstein, Mark B.; Department of Computer Science, Yale University, New Haven, Connecticut 06520, USA.; Balasubramanian, Suganthi; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA.; Chakravarti, Aravinda; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Knoppers, Bartha M.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Abecasis, Gonçalo R.; Center for Statistical Genetics and Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Bustamante, Carlos D.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Gharani, Neda; Coriell Institute, 403 Haddon Avenue, Camden, New Jersey 08103, USA.; Gibbs, Richard A.; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Jorde, Lynn; Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.; Kaye, Jane S.; Centre for Health, Law and Emerging Technologies, University of Oxford, Oxford OX3 7LF, UK.; Kent, Alastair; Genetic Alliance, 436 Essex Road, London N1 3QP, UK.; Li, Taosha; BGI-Shenzhen, Shenzhen 518083, China.; McGuire, Amy L.; Center for Medical Ethics and Health Policy, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; McVean, Gil A.; Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.; Ossorio, Pilar N.; Department of Medical History and Bioethics, University of Wisconsinâ Madison, Madison, Wisconsin 53706, USA.; Rotimi, Charles N.; US National Institutes of Health, Center for Research on Genomics and Global Health, 12 South Drive, Bethesda, Maryland 20892, USA.; Su, Yeyang; BGI-Shenzhen, Shenzhen 518083, China.; Toji, Lorraine H.; Coriell Institute, 403 Haddon Avenue, Camden, New Jersey 08103, USA.; Tyler-Smith, Chris; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Brooks, Lisa D.; US National Institutes of Health, National Human Genome Research Institute, 5635 Fishers Lane, Bethesda, Maryland 20892, USA.; Felsenfeld, Adam L.; US National Institutes of Health, National Human Genome Research Institute, 5635 Fishers Lane, Bethesda, Maryland 20892, USA.; McEwen, Jean E.; US National Institutes of Health, National Human Genome Research Institute, 5635 Fishers Lane, Bethesda, Maryland 20892, USA.; Abdallah, Assya; The George Washington University School of Medicine and Health Sciences, Washington DC 20037, USA.; Juenger, Christopher R.; US Food and Drug Administration, 11400 Rockville Pike, Rockville, Maryland 20857, USA.; Clemm, Nicholas C.; US National Institutes of Health, National Human Genome Research Institute, 5635 Fishers Lane, Bethesda, Maryland 20892, USA.; Collins, Francis S.; US National Institutes of Health, 1 Center Drive, Bethesda, Maryland 20892, USA.; Duncanson, Audrey; Wellcome Trust, Gibbs Building, 215 Euston Road, London NW1 2BE, UK.; Green, Eric D.; US National Institutes of Health, National Human Genome Research Institute, 31 Center Drive, Bethesda, Maryland 20892, USA.; Guyer, Mark S.; US National Institutes of Health, National Human Genome Research Institute, 5635 Fishers Lane, Bethesda, Maryland 20892, USA.; Peterson, Jane L.; US National Institutes of Health, National Human Genome Research Institute, 5635 Fishers Lane, Bethesda, Maryland 20892, USA.; Schafer, Alan J.; Wellcome Trust, Gibbs Building, 215 Euston Road, London NW1 2BE, UK.; Abecasis, Gonçalo R.; Center for Statistical Genetics and Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Altshuler, David; The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Department of Genetics, Harvard Medical School, Cambridge, Massachusetts 02115, USA.; Auton, Adam; Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.; Brooks, Lisa D.; US National Institutes of Health, National Human Genome Research Institute, 5635 Fishers Lane, Bethesda, Maryland 20892, USA.; Durbin, Richard M.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; Gibbs, Richard A.; Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.; Hurles, Matt E.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.; McVean, Gil A.; Department of Statistics, University of Oxford, Oxford OX1 3TG, UK.